Tuesday, October 15, 2013

Anthony Hopkins writes 'Breaking Bad' love letter

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6 hours ago

Image: Anthony Hopkins, Bryan Cranston

Getty Images, AMC

British actor Anthony Hopkins, left, has heaped high praise on Bryan Cranston for his work as Walter White on "Breaking Bad."

Oscar winner Anthony Hopkins is no slouch in the acting department, but after binge-watching all six seasons of "Breaking Bad" recently, he couldn't resist writing a letter to star Bryan Cranston to tell him it was the best acting he had seen — ever.

The letter showed up Sunday on the Facebook page of actor Steven Michael Quezada, who played DEA agent Steve Gomez on the AMC hit. It was quickly picked up across the web, but on Monday the post, along with a tweet about it from Quezada, disappeared.

Arnold Robinson, a publicist for Hopkins, confirmed to TODAY on Monday that the letter was indeed real. And a source at United Talent Agency, which represents both Hopkins and Cranston, told TODAY that Hopkins wanted to write Cranston because he admired his work so much. Hopkins was complimentary of the entire cast, and the UTA source said Cranston shared it, not expecting the letter to go viral.

Hopkins writes that he was compelled to reach out after what he refers to as two weeks of "addictive" viewing.

I have never watched anything like it. Brilliant!

Your performance as Walter White was the best acting I have seen — ever.

I know there is so much smoke blowing and sickening bull---- in this business, and I've sort of lost belief in anything really.

But this work of yours is spectacular — absolutely stunning. What is extraordinary, is the sheer power of everyone in the entire production. What was it? Five or six years in the making? How the producers (yourself being one of them), the writers, directors, cinematographers.... every department — casting etc. managed to keep the discipline and control from beginning to the end is (that over used word) awesome.

Hopkins is no stranger to portraying crafty monsters — he won his Academy Award for the role of Hannibal Lecter in 1991's "The Silence of the Lambs."

"Thank you," the 75-year-old actor writes. "That kind of work/artistry is rare, and when, once in a while, it occurs, as in this epic work, it restores confidence. You and all the cast are the best actors I've ever seen."

Cranston, 57, won three Emmys for his work as the high-school-teacher-turned-meth-kingpin Walter White. Last month he lost out to Jeff Daniels of HBO's "The Newsroom," but "Breaking Bad" won the Emmy for best drama series.








Source: http://www.today.com/entertainment/anthony-hopkins-binges-breaking-bad-writes-bryan-cranston-glowing-letter-8C11390530
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Sunday, October 13, 2013

The Top 5 Board Games That Really Will Ruin Friendships - Kotaku

One piece of trivia orbits modern board gaming like a dark, sexy star. Someone who doesn't really play them will always have heard from their friend, who heard it from another friend, that games like Game of Thrones or Battlestar Galactica are mean. They ruin friendships.


It's true that in recent years, board games have been discovering the joy of traitors and treachery. As anyone who's played a particularly tense round of poker will know, there's a strange, emotional core to table games. When you're next to somebody and sharing this experience, you really do connect with them. As I wrote for Kotaku a couple of months back, board games are emotional power adaptors.


But Game of Thrones? Battlestar Galactica? These are games where the backstabbing and twists of the knife are expected. If you really want to test your friendships, these are the games you should be playing.


The Top 5 Board Games That Really Will Ruin Friendships


Play Werewolf with friends who hold a grudge


Oh, god.


Werewolf is similar to Mafia or The Resistance, if you've played either of those. A room full of players (and candles, and spooky music if you're doing it right) take on the role of villagers, trying to find and lynch the werewolf players in their midst.


Every night all the villagers “go to sleep” by closing their eyes. The werewolves “awake” and silently decide which villager to murder. A moderator declares theatrically who's been found dead, you all decide who to lynch again, and play continues until all the werewolves are dead or there are as many werewolves as villagers. This is a game where simply announcing you trust someone can be the missing piece of the puzzle for other players.


Werewolf couldn't be simpler, but there's nothing better for bringing out the worst in people. The entire game is just scum rising to the top of a simmering pot of tension. One hapless player will always be eaten by the wolf players before the first turn of the game. In the day, players will form terrifying pitchfork mobs powered by the noisiest player's half-formed logic. If you're playing with the Hunter, their shotgun will let them take a player of their choice down with them. The secret Lovers will be trying to keep their partner alive, no matter what team they're on. There are dozens of these modules to keep the game fresh, and best of all, when anyone dies, which side they're on isn't revealed until the game's over.


But Werewolf isn't just a game that gives that friend of yours who bears grudges a lot of reasons to be upset. It's a game where that player will have to sit in impotent silence after being unfairly lynched, until the entire game is finished.


But it gets worse, because in the next game, that friend's anger becomes a tool for the werewolves to use. When the person he's angry at shows up dead, said grudge-bearing player is going to be the target for an unfair lynching again.Oh, dear.


The Top 5 Board Games That Really Will Ruin Friendships


Play Twilight Imperium with friends who role-play


Ah, Twilight Imperium. The all-you-can-eat-buffet of strategic board gaming. Here's a game where just 20 minutes might see the orbital bombardment of the human home world, a meeting of the galactic council, new trade routes being formed, a hostage exchange, someone's flagship being destroyed in an illegal minefield and someone developing the tech required to build huge, plastic War Suns.


What makes Twilight Imperium an exciting game, as opposed to just an exciting board game, is that every one of these events will impact everyone's social standing with one another. Because everybody's physically so close to one another and ships are so precious, there's an awful lot of talking in TI before anyone does anything. Everything from alliances, to non-aggression treaties, to trade embargoes are decided without the need for rules, but at the clink of a beer.


There's a problem, though. Everybody gets an alien race to play at the start of Twilight Imperium. Perhaps you'll be the grand, pompous Winnu, or maybe the Sardakk N'orr, a species of horrifying, murderous beetles.


This brings us to a problem. Some players are going to play Twilight Imperium like the po-faced strategy game it is. But the game's just so colourful and tells such a bold, bright story that players are often drawn towards “acting their race.”


Guess what happens when you sit a very serious strategy gamer between someone pretending to be a computer virus, and another pretending to be a beetle. You'll be able to see the steam coming out of their ears by the second or third council.


The Top 5 Board Games That Really Will Ruin Friendships


Play Space Alert with an incompetent


Space Alert is one of the best games I've ever played. In a mission spanning 10 real-life minutes, you and a team of three or four friends have to keep your spaceship safe against threats ranging from hostile fighter craft, to a space octopus, to asteroids, to a nuclear device in your engine room. Or possibly all of these at once.


Without a shadow of a doubt, Space Alert is the most stressful board game in my collection. Imagine trying to calculate the optimal moment to fire the starboard laser at an incoming planetoid. Now, imagine all of your friends shouting at one another (and you) while you do it. Now, imagine that if you fail, everybody dies. Now, imagine you've noticed that there's no energy in the port-side reactor, and you'll need somebody to get down there are siphon energy into it immediately. Now stop imagining because this is REALLY HAPPENING and you have TWENTY SECONDS, GO, GO, GO


Losing a game of Space Alert after trying your hardest can be pretty crushing (perhaps literally figuratively, should you encounter a black hole). Losing five games in a row is even worse. But losing ship after ship because that one friend of yours isn't paying attention, and laughs contentedly every time something goes wrong? You'll start wanting to drag him into a real-life airlock.


The Top 5 Board Games That Really Will Ruin Friendships


Play Merchants & Marauders with sore winners


Z-Man Games' Merchants & Marauders is THE pirate board game. Some people will tell you that that's Libertalia, but those people will be boring and smell of beef. Merchants & Marauders offers piracy that feels all the more illicit because players don't have to do it. You can trade goods, hunt rumours, take on missions, collect bounties on pirates or even other players. It's the table game of Sid Meier's Pirates!, except with the most aggressive local multiplayer you've ever seen.


Here's the thing about Merchants & Marauders. If two players are brave or dumb enough to fight, the winning player will receive:


  • Everything in the loser's cargo hold
  • Their ship
  • Their crew
  • All the money onboard

Sounds pretty humiliating, right? But we're not finished! They also get...


  • Any rumours the loser was holding
  • Their hand of special, one-shot action cards
  • In a very real sense, their dignity

It's the ludic equivalent of having your legs waxed. Losing all this can set you back by hours, to say nothing of watching your friend idly throwing your cargo overboard because he can't carry it all.


In the right conditions, this can be kind of character-building. Losing everything and starting from nothing again with a smile on your face? That demands spirit.


But I would never, ever play Merchants & Marauders with sore winners. To lose everything to a friend who's going to make fun of you? For hours? You're looking at the start of a suitably thematic drunken brawl.


The Top 5 Board Games That Really Will Ruin Friendships


Play Diplomacy at all


The Game of Thrones board game gets all the hype. All the talk of how its players will be performing traitorous plays that make the Red Wedding look like a Super Sweet 16.


But if you really want to put you and your friends to the test, you go to Amazon and you buy a copy of Diplomacy. Originally released in 1954, this is the original game for treacherous motherf*****s.


Each turn of Diplomacy is made up of three phases. First, everybody leaves the table to engage in private discussions with the rest of the European powers. Second, everybody writes the moves for all of their pieces. Third, everything moves at once, with very nuanced rules for “supporting” that make alliances crucial. Fourth, you do it again, having seen that bastard Russia friend was playing you the whole time, and he and Turkey are going to be carving you up like a battery hen for the next two hours.


In other words, it's Game of Thrones, but players have to look one another in the eye for 15 minutes before dicking each other over. A game so cold that it turns players abandoning the game into a feature, with their country falling into “civil disorder.”


Oh god. Am I making this sound fun? I'm trying not to. I'm serious.


Buy Diplomacy at your own risk. I will absolutely not be held accountable.


Quintin Smith is a games columnist able to identify different board game manufacturers by their scent. He is not proud of this. He's part of a team working to make a home for play in Shut Up & Sit Down, and @quinns108 on Twitter.

Source: http://kotaku.com/the-top-5-board-games-that-really-will-ruin-friendships-1443867215
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Saturday, August 3, 2013

Avatar will have three sequels, next movie is due in December 2016

When Avatar hit theaters in 2009 it was notable not only for its incredible computer rendered special effects and record breaking box office returns, but also as a touchstone for a resurgence of 3D movies. Now 20th Century Fox and director James Cameron have announced plans to build out a quadrilogy of Avatar movies. Screenwriters Rick Jaffa, Amanda Silver, Shane Salerno and Josh Friedman are all on board to collaborate on the screenplays for movies 2, 3 and 4, which will be produced by Cameron and Jon Landau's Lightstorm Entertainment. Avatar 2 is scheduled to hit theaters in December 2016, with the other movies following in 2017 and 2018. WETA remains on hand to produce the special effects, we'll see what advancements in technology (Jim's in love with high framerates but The Hobbit didn't garner a universally positive response) allow them to create this time around and if audiences come out in similar numbers -- hopefully the 3D Blu-ray (or whatever format is around) doesn't take so long to arrive at retail this time.

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Source: http://www.engadget.com/2013/08/01/avatar-sequels-start-in-2016/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Saturday, July 20, 2013

Tuesday, July 9, 2013

Molecular diagnostics company GeneCentric collects $2.5 million for cancer tests

dna stock image

Using the genetic properties of tumors to classify them more specifically and determine whether they may respond to anti-angiogenic drugs has netted a two-year-old diagnostics firm a $2.5 million round.

GeneCentric Diagnostics Inc. is now a commercial-stage company, said former LabCorp exec Dr. Myla Lai-Goldman, who is now CEO of GeneCentric and a venture partner with Hatteras Venture Partners. ?We plan to use the equity raise to continue our mission of translating important cancer discoveries into clinically adopted diagnostics for pathologists, clinicians, and most importantly, patients,? she said.

Its first product is the Lung Subtype Platform, a diagnostic that stratifies lung cancer patients into subtypes based on genes extracted from a tumor sample. It?s intended to help doctors determine the best therapeutic approaches for patients, which may include newer targeted therapies. LabCorp licensed and developed the first application of LSP, which it now offers through its specialty testing business.

A second platform, a 13-gene hypoxia signature, is under development to identify cancer patients who may respond to anti-angiogenesis inhibitors.

The advent of whole genome sequencing has driven many diagnostics companies to use gene signatures to detect disease. Now molecular diagnostics companies like GeneCentric and Biodesix are going a step further, using gene profiles to give doctors clues about what treatments would be best suited for specific patients.

Lung cancer is the second most common cancer in men and women and the deadliest among both.

Based in Durham, North Carolina, GeneCentric was established in 2011 with funding from Hatteras and intellectual property from Drs. Neil Hayes? and Chuck Perou?s laboratories at the Lineberger Comprehensive Cancer Center at the UNC School of Medicine.

[Image from FreeDigitalPhotos user Victor Habbick]

Copyright 2013 MedCity News. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Reserve your seat now for MedCity CONVERGE, to be held July 9-10 in Philadelphia. Discover strategies, solutions and startups in healthcare innovation. Be a part of this gathering where the entire healthcare ecosystem converges.



By Deanna Pogorelc MedCity News

Deanna Pogorelc is a Cleveland-based reporter who writes obsessively about life science startups across the country, looking to technology transfer offices, startup incubators and investment funds to see what?s next in healthcare. She has a bachelor?s degree in journalism from Ball State University and previously covered business and education for a northeast Indiana newspaper.
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Source: http://medcitynews.com/2013/07/molecular-diagnostics-company-genecentric-collects-2-5-million-for-cancer-tests/

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Saturday, July 6, 2013

Health insurers fear young people will opt out

MIAMI (AP) ? Dan Lopez rarely gets sick and hasn't been to a doctor in 10 years, so buying health insurance feels like a waste of money.

Even after the federal health overhaul takes full effect next year, the 24-year-old said he will probably decide to pay the $100 penalty for those who skirt the law's requirement that all Americans purchase coverage.

"I don't feel I should pay for something I don't use," said the Milwaukee resident, who makes about $48,000 a year working two part-time jobs.

Because he makes too much to qualify for government subsidies, Lopez would pay a premium of about $3,000 a year if he chose to buy health insurance.

"I shouldn't be penalized for having good health," he said.

Persuading young, healthy adults such as Lopez to buy insurance under the Affordable Care Act is becoming a major concern for insurance companies as they scramble to comply with the law, which prohibits them from denying coverage because of pre-existing conditions and limits what they can charge to older policy holders.

Experts warn a lot of these so-called "young invincibles" could opt to pay the fine instead of spending hundreds or thousands of dollars each year on insurance premiums. If enough young adults avoid the new insurance marketplace, it could throw off the entire equilibrium of the Affordable Care Act. Insurers are betting on the business of that group to offset the higher costs they will incur for older, sicker beneficiaries.

The nonpartisan Congressional Budget Office estimates that about six million people of various ages will pay the tax penalty for not having insurance in 2014, the first year the law championed by President Barack Obama will be fully implemented.

It's hard to estimate how many of those will be the young and healthy adults insurers are trying to reach, but that subgroup makes up a very small portion of the overall market. Even though it's small, experts say it could be enough to throw the system's financing off-kilter.

About 3 million 18-24 year-olds in the U.S. currently purchase their own insurance. Many pay high prices for scant benefits, with high deductibles and co-pays because they make too much to qualify for Medicaid and have no coverage options from their employers or parents. The Urban Institute estimates that the majority of adults in their 20s will qualify for government subsidies under the Affordable Care Act.

Premium hikes could be a disincentive for young people weighing their options. Premiums for people aged 21 to 29 with single coverage who are not eligible for government subsidies would increase by 42 percent under the law, according to an analysis by actuaries at the consulting firm Oliver Wyman. By comparison, an adult in his or her early 60s who would see about a 1 percent average increase in premiums under new federal health rules.

Insurers including America's Health Insurance Plans and The Blue Cross and Blue Shield Association recently wrote to federal health officials warning that they feared low enrollment by young adults and proposed beefed up penalties for opting out. Insurers worry the $100 penalty might not be a strong enough deterrent. The penalties jump to $695 or 2.5 percent of taxable income ? whichever is more ? by 2016.

"The key to keeping health care affordable is you really want to balance the pool, where you have enough young and healthy people to balance off the care of the older, sicker people who are likely to utilize much more health care services," said Justine Handelman, the Blue Cross and Blue Shield Association's vice president for legislative and regulatory policy.

She said younger people use about a fifth of the services that older beneficiaries do.

Jonathan Gruber, an economics professor at the Massachusetts Institute of Technology who helped craft that state's law, said he thinks the first-year federal penalty should be higher.

The penalty under the Massachusetts law, which served as the model for Obama's overhaul, was $218 the first year in 2007. Gruber said that amount proved effective.

"People hate paying money and getting nothing for it," he said.

Roughly 40,000 of about 6 million Massachusetts residents paid the penalty the first year, he said.

Many young adults have chosen relatively bare-bones health plans before the Affordable Care Act, but the new law requires all plans to offer a minimum set of benefits, thus raising the price for coverage.

The cost of health coverage is difficult to estimate because it includes so many factors, but a 27-year-old making $30,000 a year in 2014 will have a $3,400 premium and will be eligible for subsidies that cover about 26 percent of the bill. That person would end up paying $2,509, or about $209 a month. That does not include deductibles, co-pays and other variables which can vary widely.

The estimates come from the nonpartisan Kaiser Family Foundation's online Health Reform Subsidy Calculator.

Francois Louis, a 20-year-old college student in South Florida who works part-time, can't remember the last time he went to the doctor and gets by on over-the-counter medication whenever he's sick. He'd love to get a check-up, but says it's too expensive on his income of less than $15,000 a year.

"I probably would do the $100 fine because it's just cheaper and you don't have to worry about paying off monthly costs," said Louis, a student at Broward Community College near Fort Lauderdale.

Louis would get a $2,718 tax credit and have to pay $300 toward his premium, according to the calculator.

Health advocates note that many people who have difficulty affording health insurance now will qualify for federal subsidies. The financial assistance will go to those making less than $48,000 a year who cannot get affordable coverage through their job.

That includes 27-year-old Emily Nicoll of Dallas, who makes $20,000 a year working in customer service for a sports team.

She said she pays a lot of money for basic health benefits, including $80 a month for two prescriptions and a $100 co-pay for each doctor's visit. But the memory of being in a car accident in high school lingers, so she will continue to pay for health insurance once the new law takes effect.

"That's the fear that makes me pay out that $151 a month," said Nicoll, who says most of her friends do not have insurance.

She would receive a $2,100 tax credit under the Affordable Care Act and pay about $83 a month for her premium.

While Nicoll stands to save money on health insurance under the new law, many young people who make more money would not.

The potential for skyrocketing prices caught the attention of a Democratic state lawmaker in New Jersey, Assemblywoman Celeste Riley. She is so worried about the cost for young people that she helped pass legislation to remove a requirement that students at two-year colleges have health insurance to attend class. But Gov. Chris Christie vetoed the bill last week.

Riley said the low-cost, limited plans currently offered to students cost about $600 a year, but prices could rise up to $2,000. The Affordable Care Act allows people to stay on their parents' plans until age 26, but many parents also lack insurance in the current economy.

"In this one small situation, I have students that really are going to be hit so hard financially," she said. "I think that really some of them will decide not to go to school."

___

Associated Press writer Dinesh Ramde in Milwaukee contributed to this report.

___

Follow Kelli Kennedy on Twitter: http://twitter.com/kkennedyAP

Source: http://news.yahoo.com/health-insurers-fear-young-people-opt-153557338.html

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Tuesday, June 11, 2013

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